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KMID : 0364820140500040281
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Korean Journal of Microbiology
2014 Volume.50 No. 4 p.281 ~ p.284
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Upregulaton of Bradykinin Receptor Mediated by Nucleoside Diphosphate Kinase and Flagellin from Pseudomonas aeruginosa
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Kim Yong-Jae
Shin Hee-Sung
Shouguang Jin
Ha Un-Hwan
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Abstract
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Immune defense responses against Pseudomonas aeruginosa infection play an important role in maintaining
homeostasis in the human body. Previously, we reported that expression of the bradykinin receptor (BR) is induced
in response to P. aeruginosa infection. However, the factors responsible for the induction was uncertain. Here, we
found that the type III secretion system (T3SS) is responsible for the induction of BR expression, and nucleoside
diphosphate kinase (Ndk), as a novel T3SS effector, mediates the upregulation. The Ndk-mediated expression of BR
was not induced by fliC mutant treatment, indicating the involvement of flagellin, one of the well-known
pathogen-associated molecular patterns (PAMPs). Taken together, this study demonstrated that Ndk cooperates with
flagella in the development of defense responses against P. aeruginosa infection.
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KEYWORD
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Pseudomonas aeruginosa, bradykinin receptor, flagellin, nucleoside diphosphate kinase
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